Smoking, sex, risk factors and abdominal aortic aneurysms: a prospective study of 18â
782 persons aged above 65 years in the Southern Community Cohort Study.
J Epidemiol Community Health
; 69(5): 481-8, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25563744
ABSTRACT
BACKGROUND:
Abdominal aortic aneurysm (AAA) is a leading cause of death in the USA. We evaluated the incidence and predictors of AAA in a prospectively followed cohort.METHODS:
We calculated age-adjusted AAA incidence rates (IR) among 18â 782 participants aged ≥65â years in the Southern Community Cohort Study who received Medicare coverage from 1999-2012, and assessed predictors of AAA using multivariable Cox proportional hazards models, overall and stratified by sex, adjusting for demographic, lifestyle, socioeconomic, medical and other factors. HRs and 95% CIs were calculated for AAA in relation to factors ascertained at enrolment.RESULTS:
Over a median follow-up of 4.94â years, 281 cases were identified. Annual IR was 153/100,000, 401, 354 and 174 among blacks, whites, men and women, respectively. AAA risk was lower among women (HR 0.48, 95% CI 0.36 to 0.65) and blacks (HR 0.51, 95% CI 0.37 to 0.69). Smoking was the strongest risk factor (former HR 1.91, 95% CI 1.27 to 2.87; current HR 5.55, 95% CI 3.67 to 8.40), and pronounced in women (former HR 3.4, 95% CI 1.83 to 6.31; current HR 9.17, 95% CI 4.95 to 17). A history of hypertension (HR 1.44, 95% CI 1.04 to 2.01) and myocardial infarction or coronary artery bypass surgery (HR 1.9, 95% CI 1.37 to 2.63) was negatively associated, whereas a body mass index ≥25â kg/m(2) (HR 0.72; 95% CI 0.53 to 0.98) was protective. College education (HR 0.6, 95% CI 0.37 to 0.97) and black race (HR 0.44, 95% CI 0.28 to 0.67) were protective among men.CONCLUSIONS:
Smoking is a major risk factor for incident AAA, with a strong and similar association between men and women. Further studies are needed to evaluate benefits of ultrasound screening for AAA among women smokers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fumar
/
Aneurisma da Aorta Abdominal
/
Estilo de Vida
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Epidemiol Community Health
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos