Novel agonists of benzodiazepine receptors: design, synthesis, binding assay and pharmacological evaluation of 1,2,4-triazolo[1,5-a]pyrimidinone and 3-amino-1,2,4-triazole derivatives.

Faizi, Mehrdad; Dabirian, Sara; Tajali, Hamed; Ahmadi, Fatemeh; Zavareh, Elham Rezaee; Shahhosseini, Soraya; Tabatabai, Sayyed Abbas

Faizi, Mehrdad; Dabirian, Sara; Tajali, Hamed; Ahmadi, Fatemeh; Zavareh, Elham Rezaee; Shahhosseini, Soraya; Tabatabai, Sayyed Abbas.

Afiliação

Faizi M; Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dabirian S; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tajali H; Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ahmadi F; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zavareh ER; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahhosseini S; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tabatabai SA; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: sa_tabatabai@sbmu.ac.ir.

Bioorg Med Chem ; 23(3): 480-7, 2015 Feb 01.

Article em En | MEDLINE | ID: mdl-25564376

Assuntos

Anticonvulsivantes/farmacologia; Agonistas de Receptores de GABA-A/farmacologia; Pirimidinonas/farmacologia; Triazóis/farmacologia; Animais; Anticonvulsivantes/síntese química; Anticonvulsivantes/química; Desenho de Fármacos; Agonistas de Receptores de GABA-A/síntese química; Agonistas de Receptores de GABA-A/química; Masculino; Camundongos; Modelos Moleculares; Pirimidinonas/síntese química; Pirimidinonas/química; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Receptores de GABA-A/química; Triazóis/síntese química; Triazóis/química

Palavras-chave

Benzodiazepine agonists; Binding assay; Hypnotic activity; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Triazóis / Agonistas de Receptores de GABA-A / Anticonvulsivantes Limite: Animals Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Irã

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