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Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
Jaeschke, Georg; Kolczewski, Sabine; Spooren, Will; Vieira, Eric; Bitter-Stoll, Nadia; Boissin, Patrick; Borroni, Edilio; Büttelmann, Bernd; Ceccarelli, Simona; Clemann, Nicole; David, Beatrice; Funk, Christoph; Guba, Wolfgang; Harrison, Anthony; Hartung, Thomas; Honer, Michael; Huwyler, Jörg; Kuratli, Martin; Niederhauser, Urs; Pähler, Axel; Peters, Jens-Uwe; Petersen, Ann; Prinssen, Eric; Ricci, Antonio; Rueher, Daniel; Rueher, Marianne; Schneider, Manfred; Spurr, Paul; Stoll, Theodor; Tännler, Daniel; Wichmann, Jürgen; Porter, Richard H; Wettstein, Joseph G; Lindemann, Lothar.
Afiliação
  • Jaeschke G; Discovery Chemistry, Therapeutic Modalities, ‡Discovery Neuroscience, Neuroscience, Ophthalmology & Rare Diseases (NORD), §Communications, ∥Pharmaceutical Sciences, ⊥Molecular Design and Chemical Biology, Therapeutic Modalities, #Small Molecules Process Research and Synthesis, Therapeutic Modalities, ∞Infections Diseases, and ×Operations for Neuroscience, Ophthalmology, and Rare Diseases (NORD), Innovation Center Basel, Roche Pharmaceutical Research and Early Development , Grenzacherstrasse
J Med Chem ; 58(3): 1358-71, 2015 Feb 12.
Article em En | MEDLINE | ID: mdl-25565255
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Depressão / Descoberta de Drogas / Receptor de Glutamato Metabotrópico 5 / Síndrome do Cromossomo X Frágil / Imidazóis Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Depressão / Descoberta de Drogas / Receptor de Glutamato Metabotrópico 5 / Síndrome do Cromossomo X Frágil / Imidazóis Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article