Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

Yang, Hao; Murigi, Francis N; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude

Yang, Hao; Murigi, Francis N; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude.

Afiliação

Yang H; Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States.
Murigi FN; Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States.
Wang Z; Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States.
Li J; Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States.
Jin H; Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States.
Tu Z; Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States. Electronic address: tuz@mir.wustl.edu.

Bioorg Med Chem Lett ; 25(4): 919-24, 2015 Feb 15.

Article em En | MEDLINE | ID: mdl-25592707

Assuntos

Benzimidazóis/farmacologia; Compostos Heterocíclicos com 2 Anéis/farmacologia; Inibidores de Fosfodiesterase/farmacologia; Diester Fosfórico Hidrolases/efeitos dos fármacos; Humanos; Técnicas In Vitro

Palavras-chave

Benzimidazole analogues; Cinnoline analogues; PET; Phosphodiesterase 10A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Benzimidazóis / Diester Fosfórico Hidrolases / Compostos Heterocíclicos com 2 Anéis Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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