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In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.
Mancini, Stefano; Laurent, Frédéric; Veloso, Tiago R; Giddey, Marlyse; Vouillamoz, Jacques; Vandenesch, François; Moreillon, Philippe; Entenza, José M.
Afiliação
  • Mancini S; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
  • Laurent F; National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Center of Infectious Research, INSERM U1111, University of Lyon, Lyon, France.
  • Veloso TR; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
  • Giddey M; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
  • Vouillamoz J; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
  • Vandenesch F; National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Center of Infectious Research, INSERM U1111, University of Lyon, Lyon, France.
  • Moreillon P; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
  • Entenza JM; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland jose.entenza@unil.ch.
Antimicrob Agents Chemother ; 59(4): 2435-8, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25605361
ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with ß-lactams.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Endocardite Bacteriana / Staphylococcus aureus Resistente à Meticilina / Floxacilina / Antibacterianos Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Endocardite Bacteriana / Staphylococcus aureus Resistente à Meticilina / Floxacilina / Antibacterianos Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suíça