Concomitant mycosis fungoides and vitiligo: how mycosis fungoides may contribute to melanocyte destruction.
Dermatology
; 230(2): 143-9, 2015.
Article
em En
| MEDLINE
| ID: mdl-25634551
ABSTRACT
BACKGROUND:
Few reports have described vitiligo developing in patients with cutaneous T-cell lymphoma (CTCL).OBJECTIVE:
We sought to identify possible factors that might predispose patients with CTCL to vitiligo.METHODS:
Patient demographics, CTCL disease characteristics and treatments were analyzed in 25 patients with CTCL who developed vitiligo. Cox proportional hazards modeling was used to identify associations of risk factors with the development of vitiligo.RESULTS:
Younger age, later CTCL disease stage (stages IIB-IV) and presence of a CD8+CD4- mycosis fungoides phenotype were associated with the development of vitiligo. After adjusting for disease stage, increased risk of vitiligo was associated with methotrexate and CD4 antibody therapies (although the total number of patients with these was small), while decreased risk was associated with nitrogen mustard and PUVA therapies.CONCLUSIONS:
No single feature was common to all of our patients, suggesting that multiple factors may contribute to the development of vitiligo in a patient-specific fashion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitiligo
/
Micose Fungoide
/
Melanócitos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dermatology
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos