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The role of FoxJ2 in the migration of human glioma cells.
Qiu, Xiaojun; Ji, Bin; Yang, Lixiang; Huang, Qingfeng; Shi, Wei; Ding, Zongmei; He, Xiaojuan; Ban, Na; Fan, Shaochen; Zhang, Jianguo; Tian, Ye.
Afiliação
  • Qiu X; Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004, People's Republic of China; Department of Radiotherapy and Oncology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republ
  • Ji B; Department of Radiotherapy and Oncology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
  • Yang L; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215006, People's Republic of China.
  • Huang Q; Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
  • Shi W; Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
  • Ding Z; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
  • He X; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
  • Ban N; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
  • Fan S; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
  • Zhang J; Department of Pathology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
  • Tian Y; Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004, People's Republic of China. Electronic address: dryetian@hotmail.com.
Pathol Res Pract ; 211(5): 389-97, 2015 May.
Article em En | MEDLINE | ID: mdl-25661068
ABSTRACT
Previous studies have demonstrated that FoxJ2 (forkhead box J2) is a member of Forkhead Box transcription factors and acts as an important prognostic indicator in human breast cancer. Our study aimed to assess the expression and function in human glioma. Western blot analysis and immunohistochemistry were performed in human glioma tissues. Low FoxJ2 expression was observed in 80 samples and its level was correlated with the grade of malignancy. A strongly positive correlation was observed between FoxJ2 and E-cadherin. Overexpression of FoxJ2 increased E-cadherin expression and decreased vimentin expression. The wound healing and transwell assays showed that overexpression of FoxJ2 significantly inhibited their migration in U87 cells. Consistent with this, knockdown of FoxJ2 promoted cellular motility. In a word, FoxJ2 suppressed cell migration and invasion in glioma, which might be a potential novel molecular targeted therapy for surgery and immune treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Movimento Celular / Fatores de Transcrição Forkhead / Glioma / Invasividade Neoplásica Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Movimento Celular / Fatores de Transcrição Forkhead / Glioma / Invasividade Neoplásica Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Ano de publicação: 2015 Tipo de documento: Article