Sodium channel ß subunits: emerging targets in channelopathies.
Annu Rev Physiol
; 77: 481-504, 2015.
Article
em En
| MEDLINE
| ID: mdl-25668026
ABSTRACT
Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric complexes of α and ß subunits. Although ß subunits were originally termed auxiliary, we now know that they are multifunctional signaling molecules that play roles in both excitable and nonexcitable cell types and with or without the pore-forming α subunit present. ß subunits function in VGSC and potassium channel modulation, cell adhesion, and gene regulation, with particularly important roles in brain development. Mutations in the genes encoding ß subunits are linked to a number of diseases, including epilepsy, sudden death syndromes like SUDEP and SIDS, and cardiac arrhythmia. Although VGSC ß subunit-specific drugs have not yet been developed, this protein family is an emerging therapeutic target.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canalopatias
/
Subunidades beta do Canal de Sódio Disparado por Voltagem
/
Mutação
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Physiol
Ano de publicação:
2015
Tipo de documento:
Article