A randomized trial of levodopa as treatment for residual amblyopia in older children.
Ophthalmology
; 122(5): 874-81, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25676904
ABSTRACT
OBJECTIVE:
To assess the efficacy and short-term safety of levodopa as adjunctive treatment to patching for amblyopia.DESIGN:
Randomized, placebo-controlled trial.PARTICIPANTS:
One hundred thirty-nine children 7 to 12 years of age with residual amblyopia resulting from strabismus, anisometropia, or both combined (visual acuity [VA], 20/50-20/400) after patching.METHODS:
Sixteen weeks of oral levodopa or placebo administered 3 times daily while patching the fellow eye 2 hours daily. MAIN OUTCOMEMEASURES:
Mean change in best-corrected amblyopic-eye VA at 18 weeks.RESULTS:
At 18 weeks, amblyopic-eye VA improved from randomization by an average of 5.2 letters in the levodopa group and by 3.8 letters in the placebo group (difference adjusted for baseline VA, +1.4 letters; 1-sided P=0.06; 2-sided 95% confidence interval, -0.4 to 3.3 letters). No serious adverse effects from levodopa were reported during treatment.CONCLUSIONS:
For children 7 to 12 years of age with residual amblyopia after patching therapy, oral levodopa while continuing to patch 2 hours daily does not produce a clinically or statistically meaningful improvement in VA compared with placebo and patching.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bandagens
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Dopaminérgicos
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Levodopa
/
Ambliopia
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Ophthalmology
Ano de publicação:
2015
Tipo de documento:
Article