Independent and combined effects of cognitive and physical activity on incident MCI.
Alzheimers Dement
; 11(11): 1377-84, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25684687
ABSTRACT
INTRODUCTION:
The objective of this study was to examine the independent and combined influences of late-life cognitive activity (CA) and physical activity (PA) on the risk of incident mild cognitive impairment (MCI).METHODS:
We used interval censored survival modeling to examine the risk of incident MCI (Clinical Dementia Rating [CDR] = 0.5) as a function of CA (high vs. low) and at least moderate intensity PA (any vs. none) among 864 cognitively normal (CDR = 0) older adults.RESULTS:
During three annual follow-up waves, 72 participants developed MCI. Compared with low CA with no PA, significant reductions in risk for MCI were observed for high CA with any PA (hazards ratio (HR) = 0.20, 95% confidence interval (CI) 0.07-0.52) and low CA with any PA (HR = 0.52, 95% CI 0.29-0.93), but not for high CA without PA (HR = 0.94, 95% CI 0.45-1.95).DISCUSSION:
These findings suggest that a combination of CA and PA may be most efficacious at reducing the risk for cognitive impairment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Disfunção Cognitiva
/
Atividade Motora
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2015
Tipo de documento:
Article