Diagnosis of peripheral androgen insensitivity in a male infant excretion analysis.
Arch Androl
; 22(2): 143-7, 1989.
Article
em En
| MEDLINE
| ID: mdl-2568823
ABSTRACT
The hypothesis of peripheral androgen insensitivity (AIS) was examined in a boy with congenital growth hormone deficiency associated with micropenis and cryptorchidism by steroid excretion analyses compared with dihydrotestosterone (DHT) receptor analyses of foreskin biopsy homogenate. Urinary T metabolite 3 alpha,17 beta-dihydroxy-5 beta-androstane (3 beta-diol) was below the limit of detection (capillary gas chromatography) at age 1 year, but on several occasions (n = 7) normal basal values were found at age 3 years (patient 78.9 +/- 25.4 micrograms/24 h, M +/- SD; controls, n = 15 100.5 +/- 50.2). Normal basal- and hCG-induced excretion was noted for 3 alpha,17 beta-dihydroxy-5 alpha-androstane (3 alpha-diol) at age 1 and 3 years, respectively. Additionally, basal 3 alpha-diol excretion (n = 7) at age 3 years was 66.7 +/- 21.1 micrograms/24 h, M +/- SD; controls (n = 15) 75.8 +/- 50.4. Analysis of urinary androgens might be an alternative, noninvasive procedure for the diagnosis of peripheral AIS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Criptorquidismo
/
Androgênios
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Arch Androl
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Áustria