In vitro human metabolism of the flame retardant resorcinol bis(diphenylphosphate) (RDP).
Environ Sci Technol
; 49(6): 3897-904, 2015 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-25692932
ABSTRACT
Resorcinol bis(diphenylphosphate) (RDP) is widely used as a flame retardant in electrical/electronic products and constitutes a suitable alternative to decabrominated diphenyl ether. Due to its toxicity and its recently reported ubiquity in electronics and house dust, there are increasing concerns about human exposure to this emerging contaminant. With the aim of identifying human-specific biomarkers, the in vitro metabolism of RDP and its oligomers was investigated using human liver microsomes and human liver cytosol. Mono- and dihydroxy-metabolites, together with glucuronidated and sulfated metabolites, were detected. Regarding RDP oligomers, only a hydroxy-metabolite of the dimer could be detected. RDP and its oligomers were also readily hydrolyzed, giving rise to a variety of compounds, such as diphenyl phosphate, para-hydroxy-triphenyl phosphate, and para-hydroxy RDP, which were further metabolized. These degradation products or impurities are possibly of environmental importance in future studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organofosfatos
/
Resorcinóis
/
Biomarcadores
/
Retardadores de Chama
Limite:
Humans
Idioma:
En
Revista:
Environ Sci Technol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Bélgica