Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Autofagia/efeitos dos fármacos; Dano ao DNA; PTEN Fosfo-Hidrolase/metabolismo; Transporte Ativo do Núcleo Celular/efeitos dos fármacos; Antineoplásicos/farmacologia; Autofagia/fisiologia; Cisplatino/farmacologia; Humanos; Fosforilação/efeitos dos fármacos; Proto-Oncogene Mas; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Inibidores da Topoisomerase I/farmacologia; Topotecan/farmacologia; Proteínas Supressoras de Tumor/metabolismo

AKT/PKB, v-akt murine thymoma viral oncogene homolog; AMPK, protein kinase, AMP-activated; ATG, autophagy-related; ATM; ATM, ATM serine/threonine kinase; Baf.A1, bafilomycin A1; CASP3, caspase 3, apoptosis-related cysteine peptidase; CCND1, cyclin D1; CDDP, cisplatin; CENPC/CENP-C, centromere protein C; CITED1/p300/CBP, Cbp/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 1; CSNK2/CK2, casein kinase 2; DNA damage; DSBs, DNA double-strand breaks; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GFP, green fluorescent protein; GLTSCR2/PICT-1, glioma tumor suppressor candidate region gene 2; GSK3B, glycogen synthase kinase 3 ß; GST, glutathione S-transferase; H2A histone family; H2AFX; JUN; MAP1LC3/LC3, microtubule-associated protein 1 light chain 3; MTORC1, mechanistic target of rapamycin complex 1; MVP, major vault protein; NC, normal control; NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; PAGE, polyacrylamide gel electrophoresis; PARP, poly (ADP-ribose) polymerase 1; PI3K, phosphoinositide 3-kinase; PMSF, phenylmethanesulfonyl fluoride; PPase, protein phosphatase; PTEN; PTEN, phosphatase and tensin homolog; PtdIns(3, 4, 5)P3, phosphatidylinositol (3, 4, 5)-trisphosphate; RAD51, RAD51 recombinase; RPS6KB/p70S6K; SDS, sodium dodecyl sulfate; SESN2, sestrin 2; SQSTM1/p62, sequestosome 1; TP53, tumor protein p53; TPT, topotecan; TUBA4A, tubulin, α, 4a; WT, wild type; YFP, yellow fluorescent protein; autophagy; jun proto-oncogene; member X; ribosomal protein S6 kinase, 70kDa; siRNA, small interfering RNA; topotecan