TGF-ß signal transduction pathways and osteoarthritis.
Rheumatol Int
; 35(8): 1283-92, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25773660
ABSTRACT
Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-ß/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-ß/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-ß/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Osso e Ossos
/
Cartilagem Articular
/
Fator de Crescimento Transformador beta
/
Proteínas Morfogenéticas Ósseas
/
Proteínas Smad
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Rheumatol Int
Ano de publicação:
2015
Tipo de documento:
Article