Viral noncoding RNAs: more surprises.

Tycowski, Kazimierz T; Guo, Yang Eric; Lee, Nara; Moss, Walter N; Vallery, Tenaya K; Xie, Mingyi; Steitz, Joan A

Tycowski, Kazimierz T; Guo, Yang Eric; Lee, Nara; Moss, Walter N; Vallery, Tenaya K; Xie, Mingyi; Steitz, Joan A.

Afiliação

Tycowski KT; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Guo YE; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Lee N; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Moss WN; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Vallery TK; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Xie M; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Steitz JA; Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA joan.steitz@yale.edu.

Genes Dev ; 29(6): 567-84, 2015 Mar 15.

Article em En | MEDLINE | ID: mdl-25792595

ABSTRACT

ABSTRACT

Eukaryotic cells produce several classes of long and small noncoding RNA (ncRNA). Many DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral ncRNAs associate with proteins that are essential for their stability, function, or both. Diverse biological roles--including the regulation of viral replication, viral persistence, host immune evasion, and cellular transformation--have been ascribed to viral ncRNAs. In this review, we focus on the multitude of functions played by ncRNAs produced by animal viruses. We also discuss their biogenesis and mechanisms of action.

Assuntos

Vírus de RNA/fisiologia; RNA não Traduzido/metabolismo; RNA Viral/metabolismo; Animais; Regulação da Expressão Gênica; MicroRNAs/genética; Vírus de RNA/genética; Vírus de RNA/metabolismo; RNA não Traduzido/genética; RNA Viral/genética

Palavras-chave

gene regulation; lncRNA; miRNA; ribonucleoprotein; sisRNA; virus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / RNA Viral / RNA não Traduzido Limite: Animals Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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