[Dermatology: re-defining psoriasis]. / Dermatologie. Redéfinir Le psoriasis.
Rev Med Suisse
; 11(456-457): 49-52, 2015 Jan 14.
Article
em Fr
| MEDLINE
| ID: mdl-25799650
ABSTRACT
Psoriasis has long been regarded to be one entity, comprising both plaque-type and non plaque-type manifestations. Genetic studies now provide evidence that some pustular forms should be classified separately a mutation in the gene encoding for the interleukin 36 receptor antagonist (IL36Ra) was f6und to be associated with generalized pustular psoriasis (GPP) in several Tunesian families. This finding was subsequently confirmed in different psoriasis cohorts around the world. Additionally, gain-of-function mutations in the gene for CARD 14 were identified. Clinical implications comprise a different approach to treat GPP through blocking interleukin 1beta.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Fr
Revista:
Rev Med Suisse
Assunto da revista:
MEDICINA
Ano de publicação:
2015
Tipo de documento:
Article