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Robust enumeration of cell subsets from tissue expression profiles.
Newman, Aaron M; Liu, Chih Long; Green, Michael R; Gentles, Andrew J; Feng, Weiguo; Xu, Yue; Hoang, Chuong D; Diehn, Maximilian; Alizadeh, Ash A.
Afiliação
  • Newman AM; 1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA. [2] Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Stanford, California, USA.
  • Liu CL; 1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA. [2] Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Stanford, California, USA.
  • Green MR; 1] Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Stanford, California, USA. [2] Center for Cancer Systems Biology, Stanford University, Stanford, California, USA.
  • Gentles AJ; 1] Center for Cancer Systems Biology, Stanford University, Stanford, California, USA. [2] Department of Radiology, Stanford University, Stanford, California, USA.
  • Feng W; Department of Radiation Oncology, Stanford University, Stanford, California, USA.
  • Xu Y; Department of Cardiothoracic Surgery, Division of Thoracic Surgery, Stanford University, Stanford, California, USA.
  • Hoang CD; Department of Cardiothoracic Surgery, Division of Thoracic Surgery, Stanford University, Stanford, California, USA.
  • Diehn M; 1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA. [2] Department of Radiation Oncology, Stanford University, Stanford, California, USA. [3] Stanford Cancer Institute, Stanford University, Stanford, California, USA.
  • Alizadeh AA; 1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA. [2] Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Stanford, California, USA. [3] Center for Cancer Systems Biology, Stanford University, Stanf
Nat Methods ; 12(5): 453-7, 2015 May.
Article em En | MEDLINE | ID: mdl-25822800
ABSTRACT
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types. CIBERSORT should enable large-scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets (http//cibersort.stanford.edu/).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preservação de Tecido / Tonsila Palatina / Técnicas de Cultura de Tecidos / Transcriptoma Limite: Humans Idioma: En Revista: Nat Methods Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preservação de Tecido / Tonsila Palatina / Técnicas de Cultura de Tecidos / Transcriptoma Limite: Humans Idioma: En Revista: Nat Methods Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos