Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats.

Pahuja, Richa; Seth, Kavita; Shukla, Anshi; Shukla, Rajendra Kumar; Bhatnagar, Priyanka; Chauhan, Lalit Kumar Singh; Saxena, Prem Narain; Arun, Jharna; Chaudhari, Bhushan Pradosh; Patel, Devendra Kumar; Singh, Sheelendra Pratap; Shukla, Rakesh; Khanna, Vinay Kumar; Kumar, Pradeep; Chaturvedi, Rajnish Kumar; Gupta, Kailash Chand

Pahuja, Richa; Seth, Kavita; Shukla, Anshi; Shukla, Rajendra Kumar; Bhatnagar, Priyanka; Chauhan, Lalit Kumar Singh; Saxena, Prem Narain; Arun, Jharna; Chaudhari, Bhushan Pradosh; Patel, Devendra Kumar; Singh, Sheelendra Pratap; Shukla, Rakesh; Khanna, Vinay Kumar; Kumar, Pradeep; Chaturvedi, Rajnish Kumar; Gupta, Kailash Chand.

Afiliação

Pahuja R; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Seth K; §Academy of Scientific and Innovative Research (AcSIR), Delhi 110001, India.
Shukla A; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Shukla RK; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Bhatnagar P; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Saxena PN; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Arun J; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Chaudhari BP; â¥CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226001, India.
Patel DK; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Singh SP; §Academy of Scientific and Innovative Research (AcSIR), Delhi 110001, India.
Shukla R; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Khanna VK; §Academy of Scientific and Innovative Research (AcSIR), Delhi 110001, India.
Kumar P; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.
Chaturvedi RK; §Academy of Scientific and Innovative Research (AcSIR), Delhi 110001, India.
Gupta KC; â¥CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226001, India.

ACS Nano ; 9(5): 4850-71, 2015 May 26.

Article em En | MEDLINE | ID: mdl-25825926

Assuntos

Barreira Hematoencefálica/metabolismo; Dopamina/química; Dopamina/metabolismo; Nanopartículas/química; Doença de Parkinson/tratamento farmacológico; Doença de Parkinson/fisiopatologia; Animais; Linhagem Celular Tumoral; Dopamina/efeitos adversos; Neurônios Dopaminérgicos/metabolismo; Portadores de Fármacos/efeitos adversos; Portadores de Fármacos/química; Portadores de Fármacos/metabolismo; Liberação Controlada de Fármacos; Humanos; Ácido Láctico/química; Neostriado/efeitos dos fármacos; Neostriado/metabolismo; Oxirredução; Oxidopamina/química; Oxidopamina/farmacologia; Oxidopamina/uso terapêutico; Doença de Parkinson/metabolismo; Ácido Poliglicólico/química; Copolímero de Ácido Poliláctico e Ácido Poliglicólico; Ratos; Ratos Wistar; Receptores Dopaminérgicos/metabolismo; Segurança; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Parkinson's disease; dopamine; nanoparticles; tyrosine hydroxylase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Barreira Hematoencefálica / Dopamina / Nanopartículas Limite: Animals / Humans Idioma: En Revista: ACS Nano Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Índia

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