Glycogen synthase kinase 3ß ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production.
Nat Commun
; 6: 6765, 2015 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-25828701
ABSTRACT
TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3ß interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of GSK3ß expression or its kinase activity drastically reduces the production of inflammatory cytokines and the induction of c-Fos by decreasing ERK and p38 phosphorylation. GSK3ß physically associates with TRAF6 in a TLR3 ligand poly IC-dependent manner. TRAF6 is determined to be a direct E3 ligase for GSK3ß, and TRAF6-mediated GSK3ß ubiquitination is essential for poly IC-dependent cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Quinase 3 da Glicogênio Sintase
/
Fator 6 Associado a Receptor de TNF
/
Receptor 3 Toll-Like
/
Imunidade Inata
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Coréia do Sul