TTF-1 and napsin A on cell blocks and supernatants of pleural fluids for labeling malignant effusions.
Respirology
; 20(5): 831-3, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25873201
ABSTRACT
In this retrospective study of 80 pleural effusions, the combination of thyroid transcription factor 1 (TTF-1) and napsin A immunostaining on fluid cell blocks was positive in 80% of lung adenocarcinomas. Although measuring TTF-1 pleural fluid concentrations was of no value, quantification of napsin A levels allowed the identification of one third of the double-negative stained lung adenocarcinomas, with an overall accuracy similar to classical tumour markers for malignant-benign discrimination (sensitivity 40%, specificity 100%).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Nucleares
/
Adenocarcinoma
/
Ácido Aspártico Endopeptidases
/
Derrame Pleural Maligno
/
Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Respirology
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha