Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp.

Kim, Eun La; Wang, Haibo; Park, Ju Hee; Hong, Jongki; Choi, Jae Sue; Im, Dong Soon; Chung, Hae Young; Jung, Jee H

Kim, Eun La; Wang, Haibo; Park, Ju Hee; Hong, Jongki; Choi, Jae Sue; Im, Dong Soon; Chung, Hae Young; Jung, Jee H.

Afiliação

Kim EL; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Wang H; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Park JH; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Hong J; College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Choi JS; Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea.
Im DS; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Chung HY; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Jung JH; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: jhjung@pusan.ac.kr.

Bioorg Med Chem Lett ; 25(10): 2096-9, 2015.

Article em En | MEDLINE | ID: mdl-25881821

ABSTRACT

ABSTRACT

Four new cytochalasin derivatives (1-4), together with proxiphomin (5), were isolated from a jellyfish-derived fungus Phoma sp. The planar structures and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed moderate cytotoxicity against a small panel of human solid tumor cell lines (A549, KB, and HCT116).

Assuntos

Citocalasinas/isolamento & purificação; Fungos/química; Cifozoários/microbiologia; Animais; Citocalasinas/química; Estrutura Molecular; Estereoisomerismo

Palavras-chave

Cytochalasin; Cytotoxicity; Jellyfish-derived fungus; Nemopilema nomurai; Phoma sp.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocalasinas / Fungos / Cifozoários Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article

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