First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France.

Lavergne, Rose-Anne; Morio, Florent; Favennec, Loïc; Dominique, Stéphane; Meis, Jacques F; Gargala, Gilles; Verweij, Paul E; Le Pape, Patrice

Lavergne, Rose-Anne; Morio, Florent; Favennec, Loïc; Dominique, Stéphane; Meis, Jacques F; Gargala, Gilles; Verweij, Paul E; Le Pape, Patrice.

Afiliação

Lavergne RA; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France.
Morio F; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France.
Favennec L; EA3800, Laboratoire de Parasitologie-Mycologie, Université de Rouen et CHU de Rouen, Rouen, France.
Dominique S; Department of Pneumology, Cystic Fibrosis Center, Rouen University Hospital, Rouen, France.
Meis JF; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Gargala G; EA3800, Laboratoire de Parasitologie-Mycologie, Université de Rouen et CHU de Rouen, Rouen, France.
Verweij PE; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Le Pape P; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France patrice.le-pape@univ-nantes.fr.

Antimicrob Agents Chemother ; 59(7): 4331-5, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25918139

ABSTRACT

ABSTRACT

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.

Assuntos

Antibacterianos/farmacologia; Aspergillus fumigatus/efeitos dos fármacos; Aspergillus fumigatus/genética; Azóis/farmacologia; Sistema Enzimático do Citocromo P-450/genética; Farmacorresistência Fúngica/genética; Proteínas Fúngicas/genética; Anticorpos Antifúngicos/análise; Aspergilose/microbiologia; Fibrose Cística/microbiologia; Europa (Continente); França; Humanos; Imunoglobulina E/análise; Itraconazol/farmacologia; Masculino; Mutação/genética; Estudos Retrospectivos; Voriconazol/farmacologia; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Azóis / Proteínas Fúngicas / Sistema Enzimático do Citocromo P-450 / Farmacorresistência Fúngica / Antibacterianos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França

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