Increased lung prolyl hydroxylase and decreased glucocorticoid receptor are related to decreased surfactant protein in the growth-restricted sheep fetus.

Orgeig, Sandra; McGillick, Erin V; Botting, Kimberley J; Zhang, Song; McMillen, I Caroline; Morrison, Janna L

Orgeig, Sandra; McGillick, Erin V; Botting, Kimberley J; Zhang, Song; McMillen, I Caroline; Morrison, Janna L.

Afiliação

Orgeig S; Molecular and Evolutionary Physiology of the Lung Laboratory, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.
McGillick EV; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia; Molecular and Evolutionary Physiology of the Lung Laboratory, School of Pharmacy and Medical Sciences, San
Botting KJ; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia;
Zhang S; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia;
McMillen IC; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia;
Morrison JL; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia; Janna.Morrison@unisa.edu.au.

Am J Physiol Lung Cell Mol Physiol ; 309(1): L84-97, 2015 Jul 01.

Article em En | MEDLINE | ID: mdl-25934670

Assuntos

Retardo do Crescimento Fetal/patologia; Hipóxia Fetal/patologia; Pulmão/embriologia; Prolil Hidroxilases/metabolismo; Proteínas Associadas a Surfactantes Pulmonares/metabolismo; Surfactantes Pulmonares/metabolismo; Animais; Desenvolvimento Fetal; Retardo do Crescimento Fetal/metabolismo; Fator de Transcrição GATA6/metabolismo; Glucocorticoides/metabolismo; Hidrocortisona/sangue; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Prolina Dioxigenases do Fator Induzível por Hipóxia/metabolismo; Interleucina-1beta/metabolismo; Pulmão/enzimologia; Prolil Hidroxilases/biossíntese; Estrutura Terciária de Proteína; Proteína D Associada a Surfactante Pulmonar/metabolismo; RNA Mensageiro/genética; Receptores Adrenérgicos/metabolismo; Receptores de Glucocorticoides/metabolismo; Ovinos/genética; Transdução de Sinais; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

chronic hypoxia; fetus; prolyl hydroxylase; surfactant

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Surfactantes Pulmonares / Proteínas Associadas a Surfactantes Pulmonares / Hipóxia Fetal / Retardo do Crescimento Fetal / Prolil Hidroxilases / Pulmão Limite: Animals Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Assunto da revista: BIOLOGIA MOLECULAR / FISIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália

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