Your browser doesn't support javascript.
loading
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
Henry, James R; Kaufman, Michael D; Peng, Sheng-Bin; Ahn, Yu Mi; Caldwell, Timothy M; Vogeti, Lakshminarayana; Telikepalli, Hanumaiah; Lu, Wei-Ping; Hood, Molly M; Rutkoski, Thomas J; Smith, Bryan D; Vogeti, Subha; Miller, David; Wise, Scott C; Chun, Lawrence; Zhang, Xiaoyi; Zhang, Youyan; Kays, Lisa; Hipskind, Philip A; Wrobleski, Aaron D; Lobb, Karen L; Clay, Julia M; Cohen, Jeffrey D; Walgren, Jennie L; McCann, Denis; Patel, Phenil; Clawson, David K; Guo, Sherry; Manglicmot, Danalyn; Groshong, Chris; Logan, Cheyenne; Starling, James J; Flynn, Daniel L.
Afiliação
  • Henry JR; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Kaufman MD; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Peng SB; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Ahn YM; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Caldwell TM; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Vogeti L; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Telikepalli H; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Lu WP; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Hood MM; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Rutkoski TJ; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Smith BD; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Vogeti S; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Miller D; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Wise SC; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
  • Chun L; §Emerald Biostructures, Bainbridge Island, Washington 98110, United States.
  • Zhang X; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Zhang Y; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Kays L; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Hipskind PA; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Wrobleski AD; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Lobb KL; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Clay JM; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Cohen JD; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Walgren JL; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • McCann D; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Patel P; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Clawson DK; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Guo S; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Manglicmot D; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Groshong C; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Logan C; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Starling JJ; †Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Flynn DL; ‡Deciphera Pharmaceuticals, LLC, Waltham, Massachusetts 02451, United States.
J Med Chem ; 58(10): 4165-79, 2015 May 28.
Article em En | MEDLINE | ID: mdl-25965804
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Pirimidinas / Proteínas ras / Proteínas Proto-Oncogênicas B-raf / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Pirimidinas / Proteínas ras / Proteínas Proto-Oncogênicas B-raf / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos