Endotoxin-minimized HIV-1 p24 fused to murine hsp70 activates dendritic cells, facilitates endocytosis and p24-specific Th1 response in mice.

Krupka, M; Zachova, K; Cahlikova, R; Vrbkova, J; Novak, Z; Sebela, M; Weigl, E; Raska, M

Krupka, M; Zachova, K; Cahlikova, R; Vrbkova, J; Novak, Z; Sebela, M; Weigl, E; Raska, M.

Afiliação

Krupka M; Palacky University in Olomouc, Faculty of Medicine and Dentistry, Department of Immunology, Olomouc, Czech Republic.
Zachova K; Palacky University in Olomouc, Faculty of Medicine and Dentistry, Department of Immunology, Olomouc, Czech Republic.
Cahlikova R; Palacky University in Olomouc, Faculty of Medicine and Dentistry, Department of Immunology, Olomouc, Czech Republic.
Vrbkova J; Palacky University in Olomouc, Faculty of Science, Department of Mathematical Analysis and Applications of Mathematics, Olomouc, Czech Republic.
Novak Z; University of Alabama at Birmingham, Birmingham, USA.
Sebela M; Palacky University in Olomouc, Faculty of Science, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
Weigl E; Palacky University in Olomouc, Faculty of Medicine and Dentistry, Department of Immunology, Olomouc, Czech Republic.
Raska M; Palacky University in Olomouc, Faculty of Medicine and Dentistry, Department of Immunology, Olomouc, Czech Republic. Electronic address: raskamil@uab.edu.

Immunol Lett ; 166(1): 36-44, 2015 Jul.

Article em En | MEDLINE | ID: mdl-26021827

Assuntos

Células Dendríticas/imunologia; Endocitose/imunologia; Proteína do Núcleo p24 do HIV/imunologia; Proteínas de Choque Térmico HSP70/imunologia; Proteínas Recombinantes de Fusão/imunologia; Vacinas contra a AIDS/imunologia; Animais; Antígenos Virais/imunologia; Linfócitos T CD8-Positivos/imunologia; Apresentação Cruzada/imunologia; Endotoxinas/imunologia; Feminino; Proteína do Núcleo p24 do HIV/metabolismo; Proteínas de Choque Térmico HSP70/metabolismo; Imunização; Camundongos; Camundongos Endogâmicos BALB C; Células Th1/imunologia

Palavras-chave

HIV; HIV-1 protein p24; Heat shock protein; Vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Proteínas Recombinantes de Fusão / Proteína do Núcleo p24 do HIV / Proteínas de Choque Térmico HSP70 / Endocitose Limite: Animals Idioma: En Revista: Immunol Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: República Tcheca

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