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The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB.
Boileau, Isabelle; Tyndale, Rachel F; Williams, Belinda; Mansouri, Esmaeil; Westwood, Duncan J; Le Foll, Bernard; Rusjan, Pablo M; Mizrahi, Romina; De Luca, Vincenzo; Zhou, Qian; Wilson, Alan A; Houle, Sylvain; Kish, Stephen J; Tong, Junchao.
Afiliação
  • Boileau I; 1] Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario,
  • Tyndale RF; 1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada [3] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Williams B; 1] Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario,
  • Mansouri E; 1] Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario,
  • Westwood DJ; 1] Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario,
  • Le Foll B; 1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada [3] Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada [4] Department of Pha
  • Rusjan PM; 1] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Mizrahi R; 1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada [4] Instit
  • De Luca V; 1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada [3] Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Zhou Q; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Wilson AA; 1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Houle S; 1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Kish SJ; 1] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [4
  • Tong J; 1] Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [2] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [3] Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [4
J Cereb Blood Flow Metab ; 35(8): 1237-40, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26036940
ABSTRACT
The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions. Here, we tested whether the FAAH polymorphism affects in vivo binding of the FAAH positron emission tomography (PET) probe [(11)C]CURB ([(11)C-carbonyl]-6-hydroxy-[1,10-biphenyl]-3-yl cyclohexylcarbamate (URB694)). Participants (n=24) completed one [(11)C]CURB/PET scan and were genotyped for rs324420. Relative to C/C (58%), A-allele carriers (42%) had 23% lower [(11)C]CURB binding (λk3) in brain. We report evidence that the genetic variant rs324420 in FAAH is associated with measurable differences in brain FAAH binding as per PET [(11)C]CURB measurement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Compostos Radiofarmacêuticos / Polimorfismo de Nucleotídeo Único / Tomografia por Emissão de Pósitrons / Alelos / Amidoidrolases Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Compostos Radiofarmacêuticos / Polimorfismo de Nucleotídeo Único / Tomografia por Emissão de Pósitrons / Alelos / Amidoidrolases Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2015 Tipo de documento: Article