A perspective on the developmental toxicity of inhaled nanoparticles.
Reprod Toxicol
; 56: 118-40, 2015 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-26050605
ABSTRACT
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exposição Materna
/
Exposição por Inalação
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Desenvolvimento Embrionário
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Desenvolvimento Fetal
/
Material Particulado
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Nanopartículas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Reprod Toxicol
Assunto da revista:
EMBRIOLOGIA
/
MEDICINA REPRODUTIVA
/
TOXICOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article