&#916;122p53, a mouse model of &#916;133p53&#945;, enhances the tumor-suppressor activities of an attenuated p53 mutant.

Slatter, T L; Hung, N; Bowie, S; Campbell, H; Rubio, C; Speidel, D; Wilson, M; Baird, M; Royds, J A; Braithwaite, A W

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant.

Slatter, T L; Hung, N; Bowie, S; Campbell, H; Rubio, C; Speidel, D; Wilson, M; Baird, M; Royds, J A; Braithwaite, A W.

Afiliação

Slatter TL; Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Hung N; Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Bowie S; Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Campbell H; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia.
Rubio C; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia.
Speidel D; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia.
Wilson M; Department of Microbiology and Immunology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Baird M; Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Royds JA; Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Braithwaite AW; 1] Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand [2] Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia [3] Maurice Wilkins Centre for BioDiscovery, University of Otago, Dunedin, New Zealand.

Cell Death Dis ; 6: e1783, 2015 Jun 11.

Article em En | MEDLINE | ID: mdl-26068791

Assuntos

Dano ao DNA/genética; Linfoma de Células B/genética; Linfoma de Células B/mortalidade; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; Proteína Supressora de Tumor p53/genética; Animais; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/genética; Inibidor de Quinase Dependente de Ciclina p21/antagonistas & inibidores; Inibidores de Cisteína Proteinase/farmacologia; Modelos Animais de Doenças; Interferon gama/sangue; Interleucina-6/sangue; Leupeptinas/farmacologia; Linfoma de Células B/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mutação/genética; Ligação Proteica/efeitos dos fármacos; Ligação Proteica/genética; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Proteína Supressora de Tumor p53/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Linfoma de Células B / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Death Dis Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Nova Zelândia

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