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Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA.
Perna, Anna M; Rodrigues, Tiago; Schmidt, Thomas P; Böhm, Manja; Stutz, Katharina; Reker, Daniel; Pfeiffer, Bernhard; Altmann, Karl-Heinz; Backert, Steffen; Wessler, Silja; Schneider, Gisbert.
Afiliação
  • Perna AM; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).
  • Rodrigues T; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).
  • Schmidt TP; Department of Molecular Biology, Universität Salzburg (Austria).
  • Böhm M; Department of Biology, Universität Erlangen-Nürnberg (Germany).
  • Stutz K; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).
  • Reker D; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).
  • Pfeiffer B; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).
  • Altmann KH; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).
  • Backert S; Department of Biology, Universität Erlangen-Nürnberg (Germany).
  • Wessler S; Department of Molecular Biology, Universität Salzburg (Austria).
  • Schneider G; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland). gisbert.schneider@pharma.ethz.ch.
Angew Chem Int Ed Engl ; 54(35): 10244-8, 2015 Aug 24.
Article em En | MEDLINE | ID: mdl-26069090
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Inibidores de Proteases / Proteínas de Bactérias / Desenho de Fármacos / Helicobacter pylori / Infecções por Helicobacter / Bibliotecas de Moléculas Pequenas Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Inibidores de Proteases / Proteínas de Bactérias / Desenho de Fármacos / Helicobacter pylori / Infecções por Helicobacter / Bibliotecas de Moléculas Pequenas Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2015 Tipo de documento: Article