NMR Metabolomics Show Evidence for Mitochondrial Oxidative Stress in a Mouse Model of Polycystic Ovary Syndrome.

Selen, Ebru Selin; Bolandnazar, Zeinab; Tonelli, Marco; Bütz, Daniel E; Haviland, Julia A; Porter, Warren P; Assadi-Porter, Fariba M

Selen, Ebru Selin; Bolandnazar, Zeinab; Tonelli, Marco; Bütz, Daniel E; Haviland, Julia A; Porter, Warren P; Assadi-Porter, Fariba M.

Afiliação

Selen ES; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Bolandnazar Z; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Tonelli M; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Bütz DE; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Haviland JA; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Porter WP; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Assadi-Porter FM; Department of Zoology, Magnetic Resonance Facility at Madison, and §Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

J Proteome Res ; 14(8): 3284-91, 2015 Aug 07.

Article em En | MEDLINE | ID: mdl-26076986

Assuntos

Espectroscopia de Ressonância Magnética/métodos; Doenças Metabólicas/metabolismo; Metabolômica/métodos; Mitocôndrias/metabolismo; Estresse Oxidativo; Síndrome do Ovário Policístico/metabolismo; Aminoácidos/sangue; Aminoácidos/metabolismo; Animais; Biomarcadores/sangue; Biomarcadores/metabolismo; Ciclo do Ácido Cítrico; Modelos Animais de Doenças; Feminino; Glucocorticoides; Humanos; Hidroxibutiratos/sangue; Hidroxibutiratos/metabolismo; Rim/metabolismo; Rim/patologia; Doenças Metabólicas/sangue; Doenças Metabólicas/induzido quimicamente; Metaboloma; Camundongos; NAD/metabolismo; Via de Pentose Fosfato; Síndrome do Ovário Policístico/sangue

Palavras-chave

animal model; metabolomics; mitochondria; nuclear magnetic resonance (NMR); oxidative stress; polycystic ovary syndrome (PCOS)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Espectroscopia de Ressonância Magnética / Estresse Oxidativo / Metabolômica / Doenças Metabólicas / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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