Genetics of Phage Lysis.
Microbiol Spectr
; 2(1): MGM2-0017-2013, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-26082104
ABSTRACT
We have been witnessing an increased interest in bacteriophage studies focused on their use as antibacterial agents to fight pathogenic bacteria. This interest is a consequence of the phages' ability to lyse a bacterial host. Until recently, little was known about the mechanisms used by mycobacteriophages to induce lysis of their complex hosts. However, studies on Ms6-induced lysis have changed this scenario and provided new insights into the mechanisms of bacteriophage-induced lysis. Specific lysis protein genes have been identified in mycobacteriophage genomes, reflecting the particular mycobacterial cell envelope composition. These include enzymes that target mycolic acid-containing lipids and proteins that participate in the secretion of the phage endolysin, functioning as chaperone-like proteins. This chapter focuses on the current knowledge of mycobacteriophage-induced lysis, starting with an overview of phage lysis and basic features of the lysis players.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Bacteriólise
/
Proteínas Virais
/
Micobacteriófagos
Idioma:
En
Revista:
Microbiol Spectr
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Portugal