A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.
Angew Chem Int Ed Engl
; 54(30): 8662-4, 2015 Jul 20.
Article
em En
| MEDLINE
| ID: mdl-26096197
ABSTRACT
A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56â
ppm in a bound water molecule exchange peak between pHâ
5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Térbio
/
Imageamento por Ressonância Magnética
/
Complexos de Coordenação
Limite:
Animals
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2015
Tipo de documento:
Article