In vitro incorporation of a cell-binding protein to a lentiviral vector using an engineered split intein enables targeted delivery of genetic cargo.

Chamoun-Emanuelli, Ana M; Wright, Gus; Roger, Smith; Münch, Robert C; Buchholz, Christian J; Chen, Zhilei

Chamoun-Emanuelli, Ana M; Wright, Gus; Roger, Smith; Münch, Robert C; Buchholz, Christian J; Chen, Zhilei.

Afiliação

Chamoun-Emanuelli AM; Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, Texas, 77843.
Wright G; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas.
Roger S; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas.
Münch RC; Division of Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Buchholz CJ; Division of Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Chen Z; Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, Texas, 77843. zchen4@tamu.edu.

Biotechnol Bioeng ; 112(12): 2611-7, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26108964

Assuntos

Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; Sistemas de Liberação de Medicamentos; Terapia Genética/métodos; Lentivirus/genética; Lentivirus/fisiologia; Ligação Viral; Receptor ErbB-2/metabolismo; Receptores Virais/metabolismo; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

Palavras-chave

HER2/neu; gene therapy; lentivirus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Proteínas de Transporte / Sistemas de Liberação de Medicamentos / Lentivirus / Ligação Viral Idioma: En Revista: Biotechnol Bioeng Ano de publicação: 2015 Tipo de documento: Article

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