Focal Adhesion Proteins α- and ß-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression.
Cancer Invest
; 33(8): 387-97, 2015.
Article
em En
| MEDLINE
| ID: mdl-26115385
ABSTRACT
This study aims to address the role of focal adhesion proteins α- and ß-parvin in human colorectal carcinoma (CRC). Expression of α- and ß-parvin was examined by immunohistochemistry and real-time RT-PCR in a series of human CRC. Parvins were overexpressed in CRC and their expression correlated significantly with tumor invasion, lymph node metastasis, and disease stage. A significant positive correlation of parvins protein expression with overexpression of integrin-linked kinase, p-AKT, and nuclear ß-catenin, as well as with downregulation of E-cadherin was also observed. In conclusion, overexpression of α- and ß-parvin seems to be implicated in human colorectal cancer progression.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinina
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Neoplasias Colorretais
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Proteínas dos Microfilamentos
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Grécia