Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa.
Infection
; 44(2): 259-62, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26168861
ABSTRACT
INTRODUCTION:
We report an unusual case of acute acquired toxoplasmosis (AAT) presenting as lymphadenopathy and recurrent seizures in an immunocompetent 15-year-old boy. MATERIALS ANDMETHODS:
The patient reported an 18-day vacation to Africa (Ethiopia), 39 days prior to the first seizure. Electroencephalogram (EEG) showed sporadic single-spike or sharp-wave paroxysms and the magnetic resonance imaging (RMI) of the brain was negative. The serology for T. gondii was compatible with an acute infection defined as positive for both toxoplasma-specific IgG and IgM and a low avidity (6 %), confirmed by a reference laboratory. The patient reported other two episodes of seizures, occurring 7 days apart. He was treated with pyrimethamine plus sulfadiazine and leucovorin for 4 weeks, with an improvement of lymphadenitis and normalization of EEG. After 5 months, new seizures were reported and a diagnosis of epilepsy was done. Toxoplasma polymerase chain reaction (PCR) of cerebrospinal fluid (CSF) and blood were negative. A treatment with valproic acid was started, obtaining control of the neurological disease.CONCLUSION:
Awareness of this neurologic manifestation by clinicians is required, also in immunocompetent patients. The relationship between toxoplasmosis and recurrent seizure needs to be investigated by new studies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Viagem
/
Toxoplasmose
/
Epilepsia
Limite:
Adolescent
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Infection
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Itália