Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process.
Drug Discov Today Technol
; 13: 39-46, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26190682
ABSTRACT
Metabolomics is an innovative tool that is now emerging in the drug discovery process. Indeed, its ability to follow the dynamic perturbations in the metabolome resulting from pathologies but also from drug treatment and or/toxicity is of value for the development of new therapeutic approaches. Nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical technique for several steps of the lead discovery, validation and optimization processes, has been described, together with mass spectrometry (MS) as one of the major platform that could be used for metabolomics studies. This review highlights why NMR could be considered a key tool for the application of metabolomics in drug discovery.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Ressonância Magnética
/
Descoberta de Drogas
/
Metabolômica
Limite:
Humans
Idioma:
En
Revista:
Drug Discov Today Technol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Bélgica