Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Clin Endocrinol (Oxf)
; 83(6): 902-12, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26202150
ABSTRACT
OBJECTIVE:
To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 µg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol.DESIGN:
Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum 5·0-14·9 pmol/l; higher stratum 15·0-44·9 pmol/l). PATIENTS Infertile women of good prognosis (n = 265). MEASUREMENTS Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH.RESULTS:
Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0·001) positive dose responses were observed for the number of follicles ≥ 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients.CONCLUSIONS:
Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Antimülleriano
/
Hormônio Foliculoestimulante
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha