Isocyanate exposure and asthma in the UK vehicle repair industry.
Occup Med (Lond)
; 65(9): 713-8, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26209793
ABSTRACT
BACKGROUND:
Organic diisocyanates are a common cause of occupational asthma, particularly in motor vehicle repair (MVR) workers. The UK Health & Safety Laboratory provides screening for urinary hexamethylenediamine (UHDA), a biomarker of exposure to 1,6-hexamethylene diisocyanate (HDI). The UK Surveillance of Work-related and Occupational Respiratory Disease scheme (SWORD) has collected reports of occupational asthma since 1996.AIMS:
To compare trends in HDI exposure with trends in the incidence of work-related asthma attributed to isocyanates or paint spraying in MVR workers reported to SWORD.METHODS:
Two-level regression models were used to estimate trends in UHDA levels and work-related asthma in MVR workers reported to SWORD. The direction and magnitude of the trends were compared descriptively.RESULTS:
From 2006 to 2014, there was a significant decline in the number of urine samples with detectable levels of UHDA (odds ratio = 0.96; 95% confidence intervals 0.94-0.98) and minimal change in those over the guidance value (1.03; 1.00-1.06). Over the same period, there was a significant decline in all asthma cases attributed to isocyanates or paint spraying reported to SWORD (0.90; 0.86-0.94) and a non-significant decline among MVR workers (0.94; 0.86-1.02).CONCLUSIONS:
The simultaneous decrease in HDI exposure and incident cases of asthma reported to SWORD is temporally consistent with a reduction in exposure to airborne isocyanate leading to a reduction in asthma. Although this is not direct evidence of a causal relationship between the two trends, it is suggestive.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pintura
/
Exposição Ocupacional
/
Isocianatos
/
Exposição por Inalação
/
Poluentes Ocupacionais do Ar
/
Asma Ocupacional
/
Doenças Profissionais
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Occup Med (Lond)
Assunto da revista:
MEDICINA OCUPACIONAL
Ano de publicação:
2015
Tipo de documento:
Article