Nuclear chromatin texture to differentiate follicular and papillary carcinoma of the thyroid.
Pathol Res Pract
; 185(5): 561-6, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2626365
ABSTRACT
This study presents the results of an automatic classification of six purely papillary, five purely follicular and five mixed papillary-follicular carcinomas of the thyroid. All cases were correctly classified with only two chromatin textural parameters obtained in the Olga's scan software package developed in our laboratory. Chromatin texture lines were generated by a unidirectional grey level gradient, obtained as a natural logarithmic function of the integrated optical density of each nucleus; this increased the difference between clear papillary and granular follicular nuclei. The accuracy of the method allowed a follicular carcinoma to be correctly classified as a mixed follicular-papillary. Finally a columnar-cell carcinoma of the thyroid was detected by means of its atypical DNA histogram.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Cromatina
/
Carcinoma Papilar
/
Adenocarcinoma
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Pathol Res Pract
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Espanha