Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response.

Rojas, Jennifer M; Matsen, Miles E; Mundinger, Thomas O; Morton, Gregory J; Stefanovski, Darko; Bergman, Richard N; Kaiyala, Karl J; Taborsky, Gerald J; Schwartz, Michael W

Rojas, Jennifer M; Matsen, Miles E; Mundinger, Thomas O; Morton, Gregory J; Stefanovski, Darko; Bergman, Richard N; Kaiyala, Karl J; Taborsky, Gerald J; Schwartz, Michael W.

Afiliação

Rojas JM; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.
Matsen ME; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.
Mundinger TO; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.
Morton GJ; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.
Stefanovski D; New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kaiyala KJ; Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA.
Taborsky GJ; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA ; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Schwartz MW; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.

Mol Metab ; 4(8): 561-8, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26266088

Palavras-chave

AIRg, acute insulin response to glucose; AUC, area under the curve; BIE, basal insulin effect; CNS, central nervous system; Central FGF receptors; DI, disposition index; FGF receptor inhibitor PD173074; FGF, fibroblast growth factor; FGF19, Fibroblast growth factor-19; FGFR, fibroblast growth factor receptor; FGFRi, FGFR inhibitor; FSIGT, frequently sampled intravenous glucose tolerance test; Frequently sampled intravenous glucose tolerance test; GE, glucose effectiveness; GEZI, glucose effectiveness at zero insulin; Glucose metabolism; Ibasal, basal insulin; Kg, glucose disappearance constant; Minimal model; NEFA, non-esterified free fatty acids; SG, glucose effectiveness at basal insulin; SI, insulin sensitivity; Sympathoadrenal response; icv, intracerebroventricular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Metab Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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