Blocking the L-type Ca2+ channel (Cav 1.2) is the key mechanism for the vascular relaxing effect of Pterodon spp. and its isolated diterpene methyl-6&#945;-acetoxy-7ß-hydroxyvouacapan-17ß-oate.

de Fátima Reis, Carolina; de Andrade, Daniela Medeiros Lobo; Junior Neves, Bruno; de Almeida Ribeiro Oliveira, Leandra; Pinho, José Felippe; da Silva, Leidiane Pinha; Dos Santos Cruz, Jader; Bara, Maria Teresa Freitas; Andrade, Carolina Horta; Rocha, Matheus Lavorenti

Blocking the L-type Ca2+ channel (Cav 1.2) is the key mechanism for the vascular relaxing effect of Pterodon spp. and its isolated diterpene methyl-6α-acetoxy-7ß-hydroxyvouacapan-17ß-oate.

de Fátima Reis, Carolina; de Andrade, Daniela Medeiros Lobo; Junior Neves, Bruno; de Almeida Ribeiro Oliveira, Leandra; Pinho, José Felippe; da Silva, Leidiane Pinha; Dos Santos Cruz, Jader; Bara, Maria Teresa Freitas; Andrade, Carolina Horta; Rocha, Matheus Lavorenti.

Afiliação

de Fátima Reis C; Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil.
de Andrade DM; Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil.
Junior Neves B; Laboratory for Molecular Modeling and Drug design, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil.
de Almeida Ribeiro Oliveira L; Laboratory of Natural Products Research, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil.
Pinho JF; Laboratory of Excitable Membranes and Cardiovascular Biology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, UFMG, Brazil.
da Silva LP; Laboratory of Excitable Membranes and Cardiovascular Biology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, UFMG, Brazil.
Dos Santos Cruz J; Laboratory of Excitable Membranes and Cardiovascular Biology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, UFMG, Brazil.
Bara MT; Laboratory of Natural Products Research, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil.
Andrade CH; Laboratory for Molecular Modeling and Drug design, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil.
Rocha ML; Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil. Electronic address: matheusroch@yahoo.com.br.

Pharmacol Res ; 100: 242-9, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26296533

Assuntos

Canais de Cálcio Tipo L/metabolismo; Diterpenos/farmacologia; Fabaceae/química; Extratos Vegetais/farmacologia; Vasodilatação/efeitos dos fármacos; Vasodilatadores/farmacologia; Animais; Aorta Torácica/efeitos dos fármacos; Aorta Torácica/metabolismo; Cálcio/metabolismo; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/metabolismo; Guanilato Ciclase/metabolismo; Masculino; Relaxamento Muscular/efeitos dos fármacos; Músculo Liso Vascular/efeitos dos fármacos; Músculo Liso Vascular/metabolismo; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/metabolismo; Fenilefrina/farmacologia; Canais de Potássio/metabolismo; Ratos; Ratos Wistar

Palavras-chave

Acetylcholine chloride (PubChem CID: 6060); Bay K8644 (PubChem CID: 2303); Ca(2+) channel; Ca(2+) channel blocker; Cyclopiazonic acid (PubChem CID: 54682463); Diterpene; ODQ ([1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) (PubChem CID: 1456); Phenylephrine hydrochloride (PubChem CID: 5284443); Pterodon spp.; Tetraethylammonium chloride (PubChem CID: 5946); Vasodilation; Verapamil hydrochloride (PubChem CID: 62969)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatação / Vasodilatadores / Extratos Vegetais / Canais de Cálcio Tipo L / Diterpenos / Fabaceae Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil

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