Anticancer Mechanism of Sulfur-Containing Compounds.
Enzymes
; 37: 167-92, 2015.
Article
em En
| MEDLINE
| ID: mdl-26298460
ABSTRACT
Fruit and vegetables have traditionally represented a main source for the discovery of many biologically active substances with therapeutic values. Among the many bioactive compounds identified over the years, sulfur-containing compounds, which are present especially in the genera Allium and Brassica, have been showing a protective effect against different types of cancer. Many in vitro and in vivo studies reported that apoptosis is crucial for the anticancer effects of sulfur-containing compounds. Garlic and onion compounds and isothiocyanates contained in Brassica vegetables are able to modulate apoptosis by a wide range of mechanisms. This chapter will give an overview on the induction of apoptosis by sulfur-containing compounds in cancer cells and their different molecular mechanisms. Finally, the potential clinical implications of their proapoptotic effects will be discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Enzymes
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Itália