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P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice.
Tang, Seng Chuan; Kort, Anita; Cheung, Ka Lei; Rosing, Hilde; Fukami, Tatsuki; Durmus, Selvi; Wagenaar, Els; Hendrikx, Jeroen J M A; Nakajima, Miki; van Vlijmen, Bart J M; Beijnen, Jos H; Schinkel, Alfred H.
Afiliação
  • Tang SC; Department of Molecular Oncology, The Netherlands Cancer Institute , 1066 CX Amsterdam, The Netherlands.
  • Kort A; Department of Molecular Oncology, The Netherlands Cancer Institute , 1066 CX Amsterdam, The Netherlands.
  • Cheung KL; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek , 1066 CX Amsterdam, The Netherlands.
  • Rosing H; Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , 2333 ZA Leiden, The Netherlands.
  • Fukami T; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek , 1066 CX Amsterdam, The Netherlands.
  • Durmus S; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.
  • Wagenaar E; Department of Molecular Oncology, The Netherlands Cancer Institute , 1066 CX Amsterdam, The Netherlands.
  • Hendrikx JJ; Department of Molecular Oncology, The Netherlands Cancer Institute , 1066 CX Amsterdam, The Netherlands.
  • Nakajima M; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek , 1066 CX Amsterdam, The Netherlands.
  • van Vlijmen BJ; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.
  • Beijnen JH; Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , 2333 ZA Leiden, The Netherlands.
  • Schinkel AH; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek , 1066 CX Amsterdam, The Netherlands.
Mol Pharm ; 12(10): 3714-23, 2015 Oct 05.
Article em En | MEDLINE | ID: mdl-26317243
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Química Encefálica / Membro 1 da Subfamília B de Cassetes de Ligação de ATP / Taxoides / Carboxilesterase / Citocromo P-450 CYP3A / Antineoplásicos Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Química Encefálica / Membro 1 da Subfamília B de Cassetes de Ligação de ATP / Taxoides / Carboxilesterase / Citocromo P-450 CYP3A / Antineoplásicos Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda