Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer.

Yuan, Yin; Zhou, Xuan; Ren, Yupeng; Zhou, Shupei; Wang, Lijie; Ji, Shuangmin; Hua, Ming; Li, Liang; Lu, Wei; Zhou, Tianyan

Yuan, Yin; Zhou, Xuan; Ren, Yupeng; Zhou, Shupei; Wang, Lijie; Ji, Shuangmin; Hua, Ming; Li, Liang; Lu, Wei; Zhou, Tianyan.

Afiliação

Yuan Y; School of Pharmaceutical Science, Peking University, Beijing 100191, China.
Zhou X; School of Pharmaceutical Science, Peking University, Beijing 100191, China.
Ren Y; School of Pharmaceutical Science, Peking University, Beijing 100191, China.
Zhou S; The Department of Laboratory Animal Science, Health Science Center, Peking University, Beijing 100191, China.
Wang L; School of Pharmaceutical Science, Peking University, Beijing 100191, China.
Ji S; School of Pharmaceutical Science, Peking University, Beijing 100191, China.
Hua M; The Department of Laboratory Animal Science, Health Science Center, Peking University, Beijing 100191, China.
Li L; School of Pharmaceutical Science, Peking University, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
Lu W; School of Pharmaceutical Science, Peking University, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
Zhou T; School of Pharmaceutical Science, Peking University, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China. Electronic address: tianyanzhou@bjmu.edu.cn.

J Pharm Sci ; 104(12): 4399-4408, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26344053

Assuntos

Neoplasias da Mama/tratamento farmacológico; Desoxicitidina/análogos & derivados; Dexametasona/farmacologia; Dexametasona/farmacocinética; Animais; Antineoplásicos/farmacocinética; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Desoxicitidina/farmacocinética; Desoxicitidina/farmacologia; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Sinergismo Farmacológico; Quimioterapia Combinada/métodos; Feminino; Humanos; Células MCF-7; Camundongos Endogâmicos BALB C; Camundongos Nus; Ensaios Antitumorais Modelo de Xenoenxerto/métodos; Gencitabina

Palavras-chave

cancer chemotherapy; drug interaction; in silico modeling; pharmacokinetic/pharmacodynamic models; simulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Dexametasona / Desoxicitidina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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