A live attenuated BCG vaccine overexpressing multistage antigens Ag85B and HspX provides superior protection against Mycobacterium tuberculosis infection.

Yuan, Xuefeng; Teng, Xindong; Jing, Yukai; Ma, Jilei; Tian, Maopeng; Yu, Qi; Zhou, Lei; Wang, Ruibo; Wang, Weihua; Li, Li; Fan, Xionglin

Yuan, Xuefeng; Teng, Xindong; Jing, Yukai; Ma, Jilei; Tian, Maopeng; Yu, Qi; Zhou, Lei; Wang, Ruibo; Wang, Weihua; Li, Li; Fan, Xionglin.

Afiliação

Yuan X; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Teng X; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Jing Y; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Ma J; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Tian M; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Yu Q; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Zhou L; Beijing Pushikang Pharmaceutical Co., Ltd., Beijing, 100020, People's Republic of China.
Wang R; Beijing Pushikang Pharmaceutical Co., Ltd., Beijing, 100020, People's Republic of China.
Wang W; Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, 430030, People's Republic of China.
Li L; Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, 430030, People's Republic of China.
Fan X; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. xlfan@hust.edu.cn.

Appl Microbiol Biotechnol ; 99(24): 10587-95, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26363555

Assuntos

Aciltransferases/imunologia; Antígenos de Bactérias/imunologia; Vacina BCG/administração & dosagem; Vacina BCG/imunologia; Proteínas de Bactérias/imunologia; Tuberculose/prevenção & controle; Aciltransferases/biossíntese; Aciltransferases/genética; Animais; Antígenos de Bactérias/biossíntese; Antígenos de Bactérias/genética; Vacina BCG/genética; Proteínas de Bactérias/biossíntese; Proteínas de Bactérias/genética; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD8-Positivos/imunologia; Modelos Animais de Doenças; Camundongos Endogâmicos C57BL; Mycobacterium bovis/genética; Mycobacterium bovis/imunologia; Mycobacterium tuberculosis/genética; Mycobacterium tuberculosis/imunologia; Tuberculose/imunologia; Vacinas Atenuadas/administração & dosagem; Vacinas Atenuadas/genética; Vacinas Atenuadas/imunologia; Vacinas Sintéticas/administração & dosagem; Vacinas Sintéticas/genética; Vacinas Sintéticas/imunologia

Palavras-chave

Ag85B; HspX; Overexpresssion; Recombinant BCG; Tuberculosis; Vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Tuberculose / Aciltransferases / Vacina BCG / Antígenos de Bactérias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2015 Tipo de documento: Article

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