Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys.

Glassman, Patrick M; Chen, Yang; Balthasar, Joseph P

Glassman, Patrick M; Chen, Yang; Balthasar, Joseph P.

Afiliação

Glassman PM; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, 452 Kapoor Hall, Buffalo, NY, 14214, USA.
Chen Y; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, 452 Kapoor Hall, Buffalo, NY, 14214, USA.
Balthasar JP; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, 452 Kapoor Hall, Buffalo, NY, 14214, USA. jb@buffalo.edu.

J Pharmacokinet Pharmacodyn ; 42(5): 527-40, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26364301

Assuntos

Anticorpos Monoclonais/farmacocinética; Animais; Anticorpos Monoclonais Humanizados/farmacocinética; Haplorrinos; Modelos Biológicos; Método de Monte Carlo; Distribuição Tecidual/fisiologia

Palavras-chave

Monoclonal antibody; Pharmacokinetics; Physiologically-based

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Pharmacokinet Pharmacodyn Assunto da revista: FARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google