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Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival.
Megchelenbrink, Wout; Katzir, Rotem; Lu, Xiaowen; Ruppin, Eytan; Notebaart, Richard A.
Afiliação
  • Megchelenbrink W; Institute for Computing and Information Science, Radboud University, Nijmegen, 6525 EC Nijmegen, The Netherlands; Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands; Centre for Systems Biology and Bioenergetics, Radboud University
  • Katzir R; Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, MD 20742;
  • Lu X; Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands;
  • Ruppin E; Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, MD 20742; School of Computer Science and School of Medicine, Tel-Aviv University, Tel Aviv, Israel, 69978; ruppin@post.tau.ac.il richard.notebaart@radboudumc.nl.
  • Notebaart RA; Department of Internal Medicine, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands ruppin@post.tau.ac.il richard.notebaart@radboudumc.nl.
Proc Natl Acad Sci U S A ; 112(39): 12217-22, 2015 Sep 29.
Article em En | MEDLINE | ID: mdl-26371301
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Dosagem de Genes / Biologia de Sistemas / Redes e Vias Metabólicas / Genes Letais / Modelos Genéticos / Neoplasias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Dosagem de Genes / Biologia de Sistemas / Redes e Vias Metabólicas / Genes Letais / Modelos Genéticos / Neoplasias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article