Auditory Function in Immature Animals after Two Consecutive Courses of Ototoxic Antibiotics.
Bull Exp Biol Med
; 159(4): 415-9, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26385408
ABSTRACT
In chronic experiments on immature rabbits receiving therapeutic courses of vancomycin, gentamicin, and consecutive administration of vancomicin and gentamicin by the scheme used in neonatology, hearing function was evaluated by the methods of auditory evoked potentials (auditory brainstem response, ABR) and distortion product otoacoustic emission (DPOAE). Comparison with the control group revealed ototoxic effects of all studied antibiotics that manifested in increased sound tolerance and more rapid shortening of latencies in 30-100 dB range. Higher thresholds were found only after gentamicin administration. Vancomycin administration significantly reduced the responses at 4 kHz. Subsequent gentamicin course did not potentiate this effect.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gentamicinas
/
Vancomicina
/
Potenciais Evocados Auditivos do Tronco Encefálico
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Federação Russa