Association of CCR5Δ32 and Behçet's disease: new data from a case-control study in the Spanish population and meta-analysis.
Clin Exp Rheumatol
; 33(6 Suppl 94): S96-100, 2015.
Article
em En
| MEDLINE
| ID: mdl-26393284
ABSTRACT
OBJECTIVES:
Behçet's disease (BD) is an immune-mediated and complex disease associated with HLA class I and other genes. The aim of this study was to contribute to a better understanding of the relationship of the 32-bp deletion in the CCR5 gene (CCR5Δ32) and this disease by conducting a case-control study in the Spanish population and also a meta-analysis including all the studies available to date.METHODS:
A cohort composed of 348 BD Spanish patients and 477 unrelated healthy and ethnically matched individuals were genotyped in CCR5Δ32 using polymerase chain reaction (PCR) and capillary electrophoresis with fluorescent detection. In the meta-analysis, data from a total of seven populations extracted from four previous studies along with data of the present study were included.RESULTS:
Regarding the case-control study, no statistically significant differences were observed when the patient and control groups were compared (allelic model 0.07 in patients vs. 0.06 in controls, p=0.303). In the meta-analysis, no evidence of association of the CCR5Δ32 polymorphism with BD was observed (pMH=0.091; OR=1.22; 95%CI 0.98 to 1.52 in the allelic model).CONCLUSIONS:
The results of this meta-analysis discard a major role of the CCR5Δ32 polymorphism in BD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Behçet
/
Receptores CCR5
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha