Diagnostic Accuracy of Tumor Markers CYFRA21-1 and CA125 in the Differential Diagnosis of Ascites.
Anticancer Res
; 35(10): 5655-60, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26408739
ABSTRACT
BACKGROUND:
The usefulness of tumor markers in the differential diagnosis of cancer in patients with ascites remains a matter of controversy. Few studies have reported the measurement of cancer antigen 125 (CA125) and cytokeratin 19 soluble fragments (CYFRA21-1) in ascitic fluid. The aim of the present study was to evaluate the diagnostic accuracy of these tumor markers in the detection of malignant ascites. MATERIALS ANDMETHODS:
We analyzed CA125 and CYFRA21-1 from 143 consecutive undiagnosed patients with ascitis.RESULTS:
Use of CA125 gave a sensitivity of 39.7% and a specificity of 98.8%, and CYFRA21-1 a sensitivity of 50.0% and a specificity of 97.6% in differential diagnosis of malignant ascites. For combined use of CA125 plus CYFRA21-1, sensitivity was 65.5% and specificity 96.5%. In patients with negative cytology, these two tumor markers had a sensitivity of 50% and a specificity of 96.5%.CONCLUSION:
The determination of tumor markers in ascitic fluid could be useful for the diagnostic assessment of patients with ascites.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascite
/
Biomarcadores Tumorais
/
Derrame Pleural Maligno
/
Antígeno Ca-125
/
Queratina-19
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Antígenos de Neoplasias
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha